Can I use
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Web Audio API

- WD

High-level JavaScript API for processing and synthesizing audio

IE

  1. 5.5 - 10: Not supported
  2. 11: Not supported

Edge

  1. 12 - 85: Supported
  2. 86: Supported

Firefox

  1. 2 - 24: Not supported
  2. 25 - 80: Supported
  3. 81: Supported
  4. 82 - 83: Supported

Chrome

  1. 4 - 9: Not supported
  2. 10 - 33: Supported
  3. 34 - 85: Supported
  4. 86: Supported
  5. 87 - 89: Supported

Safari

  1. 3.1 - 5.1: Not supported
  2. 6 - 13.1: Supported
  3. 14: Supported
  4. TP: Supported

Opera

  1. 9 - 12.1: Not supported
  2. 15 - 21: Supported
  3. 22 - 70: Supported
  4. 71: Supported

iOS Safari

  1. 3.2 - 5.1: Not supported
  2. 6 - 13.7: Supported
  3. 14: Supported

Opera Mini

  1. all: Not supported

Android Browser

  1. 2.1 - 4.4.4: Not supported
  2. 81: Supported

Blackberry Browser

  1. 7: Not supported
  2. 10: Not supported

Opera Mobile

  1. 10 - 12.1: Not supported
  2. 59: Supported

Chrome for Android

  1. 85: Supported

Firefox for Android

  1. 79: Supported

IE Mobile

  1. 10: Not supported
  2. 11: Not supported

UC Browser for Android

  1. 12.12: Supported

Samsung Internet

  1. 4 - 11.2: Supported
  2. 12.0: Supported

QQ Browser

  1. 10.4: Supported

Baidu Browser

  1. 7.12: Supported

KaiOS Browser

  1. 2.5: Supported

Not all browsers with support for the Audio API also support media streams (e.g. microphone input). See the getUserMedia/Streams API data for support for that feature.

Firefox versions < 25 support an alternative, deprecated audio API.

Chrome support went through some changes as of version 36.

Resources:
Additional browser compatibility tests for specific features
MDN Web Docs - Web Audio API
Polyfill to support Web Audio API in Firefox
Polyfill to enable Web Audio API through Firefox Audio Data api or flash
WebPlatform Docs