Can I use File API?

Compatibility table for support of File API in desktop and mobile browsers.

Legend

File API

- WD

Method of manipulating file objects in web applications client-side, as well as programmatically selecting them and accessing their data.

IE

  1. 5.5
  2. 6
  3. 7
  4. 8
  5. 9
  6. 10
  7. 11

Firefox

  1. 2
  2. 3
  3. 3.5
  4. 3.6
  5. 4
  6. 5
  7. 6
  8. 7
  9. 8
  10. 9
  11. 10
  12. 11
  13. 12
  14. 13
  15. 14
  16. 15
  17. 16
  18. 17
  19. 18
  20. 19
  21. 20
  22. 21
  23. 22
  24. 23
  25. 24
  26. 25
  27. 26
  28. 27
  29. 28
  30. 29
  31. 30
  32. 31
  33. 32
  34. 33
  35. 34

Chrome

  1. 4
  2. 5
  3. 6
  4. 7
  5. 8
  6. 9
  7. 10
  8. 11
  9. 12
  10. 13
  11. 14
  12. 15
  13. 16
  14. 17
  15. 18
  16. 19
  17. 20
  18. 21
  19. 22
  20. 23
  21. 24
  22. 25
  23. 26
  24. 27
  25. 28
  26. 29
  27. 30
  28. 31
  29. 32
  30. 33
  31. 34
  32. 35
  33. 36
  34. 37
  35. 38
  36. 39

Safari

  1. 3.1
  2. 3.2
  3. 4
  4. 5
  5. 5.1
  6. 6
  7. 6.1
  8. 7
  9. 8

Opera

  1. 9
  2. 9.5-9.6
  3. 10.0-10.1
  4. 10.5
  5. 10.6
  6. 11
  7. 11.1
  8. 11.5
  9. 11.6
  10. 12
  11. 12.1
  12. 15
  13. 16
  14. 17
  15. 18
  16. 19
  17. 20
  18. 21
  19. 22
  20. 23
  21. 24

iOS Safari

  1. 3.2
  2. 4.0-4.1
  3. 4.2-4.3
  4. 5.0-5.1
  5. 6.0-6.1
  6. 7.0-7.1
  7. 8

Opera Mini

  1. 5.0-7.0

Android Browser

  1. 2.1
  2. 2.2
  3. 2.3
  4. 3
  5. 4
  6. 4.1
  7. 4.2-4.3
  8. 4.4
  9. 4.4.3

Blackberry Browser

  1. 7
  2. 10

Opera Mobile

  1. 10
  2. 11
  3. 11.1
  4. 11.5
  5. 12
  6. 12.1
  7. 22

Chrome for Android

  1. 35

Firefox for Android

  1. 30

IE Mobile

  1. 10

Partial support in older Safari and other WebKit browsers refers to lacking FileReader support.

Resources:
WebPlatform Docs
MDN article
Sub-features:
Blob constructing
FileReader API
Blob URLs

*Global usage share statistics based on data from StatCounter GlobalStats for June, 2014. See the browser usage table for usage by browser version.