Can I use
?

CSS font-smooth

- UNOFF

Controls the application of anti-aliasing when fonts are rendered.

Chrome

  1. ❌ 4: Not supported
  2. ◐ 5 - 156: Partial support
  3. ◐ 157: Partial support
  4. ◐ 158 - 160: Partial support

Edge

  1. ❌ 12 - 18: Not supported
  2. ◐ 79 - 155: Partial support
  3. ◐ 156: Partial support

Safari

  1. ❌ 3.1 - 3.2: Not supported
  2. ◐ 4 - 27.1: Partial support
  3. ◐ 27.2: Partial support
  4. ◐ 27.3 - TP: Partial support

Firefox

  1. ❌ 2 - 24: Not supported
  2. ◐ 25 - 127: Partial support
  3. ◐ 128 - 159: Partial support
  4. ◐ 160: Partial support
  5. ◐ 161 - 163: Partial support

Opera

  1. ❌ 9 - 12.1: Not supported
  2. ◐ 15 - 138: Partial support
  3. ◐ 139: Partial support

IE

  1. ❌ 5.5 - 10: Not supported
  2. ❌ 11: Not supported

Chrome for Android

  1. ❌ 157: Not supported

Safari on iOS

  1. ❌ 3.2 - 26.6: Not supported
  2. ❌ 27.0: Not supported
  3. ❌ 27.1 - 27.2: Not supported

Samsung Internet

  1. ❌ 4 - 30: Not supported
  2. ❌ 31: Not supported

Opera Mini

  1. ❌ all: Not supported

Opera Mobile

  1. ❌ 10 - 12.1: Not supported
  2. ❌ 80: Not supported

UC Browser for Android

  1. ❌ 15.5: Not supported

Android Browser

  1. ❌ 2.1 - 4.4.4: Not supported
  2. ❌ 157: Not supported

Firefox for Android

  1. ❌ 160: Not supported

QQ Browser

  1. ❌ 14.9: Not supported

Baidu Browser

  1. ❌ 13.52: Not supported

KaiOS Browser

  1. ◐ 2.5: Partial support
  2. ◐ 3: Partial support

Though present in early (2002) drafts of CSS3 Fonts, font-smooth has been removed from this specification and is currently not on the standard track.

Resources:
MDN Web Docs - font-smooth
WHATWG compat issue to spec `-webkit-font-smoothing: antialiased`
Old version of W3C recommendation containing font-smooth