Can I use XHTML served as application/xhtml+xml?

Compatibility table for support of XHTML served as application/xhtml+xml in desktop and mobile browsers.

Legend

XHTML served as application/xhtml+xml

- REC

A strict form of HTML, and allows embedding of other XML languages

IE

  1. 5.5
  2. 6
  3. 7
  4. 8
  5. 9
  6. 10
  7. 11

Firefox

  1. 2
  2. 3
  3. 3.5
  4. 3.6
  5. 4
  6. 5
  7. 6
  8. 7
  9. 8
  10. 9
  11. 10
  12. 11
  13. 12
  14. 13
  15. 14
  16. 15
  17. 16
  18. 17
  19. 18
  20. 19
  21. 20
  22. 21
  23. 22
  24. 23
  25. 24
  26. 25
  27. 26
  28. 27
  29. 28
  30. 29
  31. 30
  32. 31
  33. 32
  34. 33
  35. 34

Chrome

  1. 4
  2. 5
  3. 6
  4. 7
  5. 8
  6. 9
  7. 10
  8. 11
  9. 12
  10. 13
  11. 14
  12. 15
  13. 16
  14. 17
  15. 18
  16. 19
  17. 20
  18. 21
  19. 22
  20. 23
  21. 24
  22. 25
  23. 26
  24. 27
  25. 28
  26. 29
  27. 30
  28. 31
  29. 32
  30. 33
  31. 34
  32. 35
  33. 36
  34. 37
  35. 38
  36. 39

Safari

  1. 3.1
  2. 3.2
  3. 4
  4. 5
  5. 5.1
  6. 6
  7. 6.1
  8. 7
  9. 8

Opera

  1. 9
  2. 9.5-9.6
  3. 10.0-10.1
  4. 10.5
  5. 10.6
  6. 11
  7. 11.1
  8. 11.5
  9. 11.6
  10. 12
  11. 12.1
  12. 15
  13. 16
  14. 17
  15. 18
  16. 19
  17. 20
  18. 21
  19. 22
  20. 23
  21. 24

iOS Safari

  1. 3.2
  2. 4.0-4.1
  3. 4.2-4.3
  4. 5.0-5.1
  5. 6.0-6.1
  6. 7.0-7.1
  7. 8

Opera Mini

  1. 5.0-7.0

Android Browser

  1. 2.1
  2. 2.2
  3. 2.3
  4. 3
  5. 4
  6. 4.1
  7. 4.2-4.3
  8. 4.4
  9. 4.4.3

Blackberry Browser

  1. 7
  2. 10

Opera Mobile

  1. 10
  2. 11
  3. 11.1
  4. 11.5
  5. 12
  6. 12.1
  7. 22

Chrome for Android

  1. 36

Firefox for Android

  1. 31

IE Mobile

  1. 10

The XHTML syntax is very close to HTML, and thus is almost always (incorrectly) served as text/html on the web.

Resources:
WebPlatform Docs
Wikipedia
Information on XHTML5
Sub-features:
XHTML+SMIL animation

*Global usage share statistics based on data from StatCounter GlobalStats for July, 2014. See the browser usage table for usage by browser version.