Can I use
?

CSS Initial Letter

- WD

Method of creating an enlarged cap, including a drop or raised cap, in a robust way.

Chrome

  1. 4 - 109: Not supported
  2. 110 - 112: Partial support
  3. 113: Partial support
  4. 114 - 116: Partial support

Edge

  1. 12 - 109: Not supported
  2. 110 - 112: Partial support
  3. 113: Partial support

Safari

  1. 3.1 - 8: Not supported
  2. 9: Partial support
  3. 9.1 - 16.4: Partial support
  4. 16.5: Partial support
  5. 16.6 - TP: Partial support

Firefox

  1. 2 - 112: Not supported
  2. 113: Not supported
  3. 114 - 115: Not supported

Opera

  1. 9 - 97: Not supported
  2. 98: Partial support
  3. 99: Partial support

IE

  1. 5.5 - 10: Not supported
  2. 11: Not supported

Chrome for Android

  1. 113: Partial support

Safari on iOS

  1. 3.2 - 8.4: Not supported
  2. 9 - 16.4: Partial support
  3. 16.5: Partial support

Samsung Internet

  1. 4 - 20: Not supported
  2. 21: Supported

Opera Mini

  1. all: Not supported

Opera Mobile

  1. 10 - 12.1: Not supported
  2. 73: Not supported

UC Browser for Android

  1. 13.4: Not supported

Android Browser

  1. 2.1 - 4.4.4: Not supported
  2. 113: Not supported

Firefox for Android

  1. 113: Not supported

QQ Browser

  1. 13.1: Not supported

Baidu Browser

  1. 13.18: Not supported

KaiOS Browser

  1. 2.5: Not supported
  2. 3: Not supported
Resources:
WebKit bug to unprefix -webkit-initial-letter
Firefox Implementation Ticket
MDN Web Docs - CSS initial-letter
Demos at Jen Simmons Labs
Blog post on Envato Tuts+, "Better CSS Drop Caps With initial-letter"