Can I use
?

File System Access API

- UNOFF

API for manipulating files in the device's local file system (not in a sandbox).

IE

  1. 5.5 - 10: Not supported
  2. 11: Not supported

Edge

  1. 12 - 18: Not supported
  2. 79 - 85: Disabled by default
  3. 86 - 102: Partial support
  4. 103: Partial support

Firefox

  1. 2 - 101: Not supported
  2. 102: Not supported
  3. 103 - 104: Not supported

Chrome

  1. 4 - 73: Not supported
  2. 74 - 85: Disabled by default
  3. 86 - 102: Partial support
  4. 103: Partial support
  5. 104 - 106: Partial support

Safari

  1. 3.1 - 15.1: Not supported
  2. 15.2 - 15.4: Partial support
  3. 15.5: Partial support
  4. 16.0 - TP: Partial support

Opera

  1. 9 - 60: Not supported
  2. 62 - 71: Disabled by default
  3. 72 - 85: Partial support
  4. 86: Partial support
  5. 87: Partial support

Safari on iOS

  1. 3.2 - 15.1: Not supported
  2. 15.2 - 15.4: Partial support
  3. 15.5: Partial support
  4. 16.0: Partial support

Opera Mini

  1. all: Not supported

Android Browser

  1. 2.1 - 4.4.4: Not supported
  2. 103: Not supported

Opera Mobile

  1. 10 - 12.1: Not supported
  2. 64: Not supported

Chrome for Android

  1. 103: Not supported

Firefox for Android

  1. 101: Not supported

UC Browser for Android

  1. 12.12: Not supported

Samsung Internet

  1. 4 - 16.0: Not supported
  2. 17.0: Not supported

QQ Browser

  1. 10.4: Not supported

Baidu Browser

  1. 7.12: Not supported

KaiOS Browser

  1. 2.5: Not supported
Resources:
Chrome blog post
Explainer
Firefox position: harmful
Web.dev blog post